გიორგი ხარებავა

ქართულ-ამერიკულ უნივერსიტეტში გიორგი ხარებავა კითხულობს შემდეგ სალექციო კურსს:

• უჯრედის ბიოლოგია

პუბლიკაციები

• Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology. 2017 Oct; 125:376-385.
• Lee JW, Huang BX, Kwon H, Rashid MA, Kharebava G, Desai A, Patnaik S, Marugan J, Kim HY. Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function. Nat Commun. 2016 Oct 19; 7:13123.
• Kharebava G, Rashid MA, Lee JW, Sarkar S, Kevala K, Kim HY. N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons. Biol Open. 2015;4(12):1660-70.
• Rashid MA, Katakura M, Kharebava G, Kevala K, Kim HY. N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. J Neurochem. 2013;125(6):869-84.
• Kirpich I, Zhang J, Gobejishvili L, Kharebava G, Barker D, Ghare S, et al. Binge ethanol-induced HDAC3 down-regulates Cpt1alpha expression leading to hepatic steatosis and injury. Alcohol Clin Exp Res. 2013;37(11):1920-9.
• Wu J, Kharebava G, Piao C, Stoica BA, Dinizo M, Sabirzhanov B, et al. Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo. PLoS One. 2012;7(7):e42129.
• Kirpich I, Ghare S, Zhang J, Gobejishvili L, Kharebava G, Barve SJ, et al. Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3. Alcohol Clin Exp Res. 2012;36(9):1578-86.
• Kabadi SV, Stoica BA, Hanscom M, Loane DJ, Kharebava G, Murray Ii MG, et al. CR8, a selective and potent CDK inhibitor, provides neuroprotection in experimental traumatic brain injury. Neurotherapeutics. 2012;9(2):405-21.
• Jani TS, Gobejishvili L, Hote PT, Barve AS, Joshi-Barve S, Kharebava G, et al. Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells. Cell Res. 2009;19(3):358-69.
• Kharebava G, Makonchuk D, Kalita KB, Zheng JJ, Hetman M. Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival. J Neurosci. 2008;28(44):11409-20.
• Szatmari E, Kalita KB, Kharebava G, Hetman M. Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2. J Neurosci. 2007;27(42):11389-400.
• Kalita K, Kharebava G, Zheng JJ, Hetman M. Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity. J Neurosci. 2006;26(39):10020-32.
• Hetman M, Kharebava G. Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem. 2006;6(8):787-99.
• Habas A, Kharebava G, Szatmari E, Hetman M. NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis. J Neurochem. 2006;96(2):335-48.
• Seyfried J, Wang X, Kharebava G, Tournier C. A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol. 2005;25(22):9820-8.
• Chkhikvishvili ID, Kharebava GI. [Chicoric and chlorogenic acids in various plants growing in Georgia]. Prikl Biokhim Mikrobiol. 2001;37(2):214-7.
• Javakhishvili N, Tsagareli Z, Sanikidze T, Machavariani M, Bakhutasvili Z, Enukidze M, Kharebava G, Bakhutashvili V. Antioxidant effect of Plaferon LB during myocardial infarction. Experimental and Clinical Medicine 2001;2(3):11-14
• Kharebava G, Garishvili T, Mikeladze D, Bakhutashvili V. Chromatographic profiles of Plaferon LB. Bull. Georgian Acad. Sci. 2001;163(2):341-4
• Chkhikvishvili I, Kharebava G. Quantitative analysis of Chlorogenic acid by HPLC in various grades of apples. Bull. Georgian Acad. Sci. 2001;163(2):357-60
• Jariashvili T, Kharebava G. Regulation of Na+, K+-ATPase activity by synaptosomal proteins. Bull. Georgian Acad. Sci. 2000;162(1):558-60
• Kharebava G, Todadze K, Shanshiashvili L, Zaalishvili E, Sanikidze T, Bakhutashvili A, Lezhava G, Mikeladze D. Influences of Plaferon-LB, P6 and Metadoxine on the amino acid content, nitric oxide biosynthesis and intensity of the EPR signals in the brain of alcoholized rats. Proc. Georgian Acad. Sci. Biol. Ser. 1999;25:77-86
• Kharebava G, Pantsulaia I, Chikovani T, Cheishvili N, Bakhutashvili V. Regulation of lymphocyte function by peptide fractions from Plaferon LB. Proc. Georgian Acad. Sci. Biol. Ser. 1999;25:87-90

საკონფერენციო შრომები (შერჩეული)

• Kharebava G, Sarkar S, Kim HY (2014) Role of PP2A in N-docosahexaenoylethanolamine mediated axonal development. Cell Biology of the Neuron. Gordon Research Conference Mechanistic Insight into Neuronal Development, Plasticity, Disease and Regeneration. June 22-27, Waterville Valley, NH
• Kharebava G, Kim HY (2012) Regulation of axonal morphogenesis by docosahexaenoic acid and its ethanolamide derivative, Synaptamide. SFN 42nd annual meeting Oct. 13 -17, New Orleans, LA
• Kirpich I, Zhang J, Gobejishvili L, Kharebava G, McClain C, Barve S (2010) Binge alcohol exposure inhibits hepatic class I and II histone deacetylases (HDACs): Potential mechanism for alcohol induced liver injury. FASEB Experimental Biology, April 24-28, Anaheim, CA
• Kharebava G, Hetman M. (2007) MAPK pro-survival cascade integrates PDK1 signals to protect trophic deprived cortical neurons. FASEB summer research conferences, Protein kinase and protein  phosphorylation, July 7-12, Indian Wells, CA
• Kharebava G, Hetman M. (2006) Critical Role of p90RSK in neuronal survival. Gordon research conferences, Growth Factor Signaling, July 16-21, Connecticut College, CT
• Kharebava G, Bakhutashvili V. (2001) Nitric oxide production in rat brain during alcohol loading and withdrawal: influence by peptide – P6 purified from human amnion. NATO advanced research workshop – Creatine Kinase and Brain Energy Metabolism July 14-18, Tbilisi, Georgia
• Bakhutashvili V, Gagua M, Garishvili T, Gelashvili L, Kharebava G, Kvaratskhelia E. (1997) Human placenta antioxidant compounds of peptide nature. 11th International Symposium on Atherosclerosis. Paris, October, 134, 199